Dose and Dosage:
- The dosage of bromfenac depends on the formulation (eye drops or tablets), the specific condition being treated, and the patient’s individual response.
- For ophthalmic use (eye drops), the typical dose is one drop instilled into the affected eye(s) once daily, starting the day before cataract surgery and continuing for 14 days postoperatively.
- For systemic use (tablets), the dosage varies depending on the indication and may range from 25 mg to 50 mg once daily.
Frequency:
- The frequency of administration for ophthalmic use is typically once daily.
- For systemic use, bromfenac tablets are usually taken once daily.
Route of Administration (ROA):
- Bromfenac is available in ophthalmic formulations for topical administration to the eyes (eye drops) and oral tablets for systemic use.
Mechanism of Action (MOA):
- Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits the enzyme cyclooxygenase (COX), thereby reducing the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever.
Pharmacokinetics (PK):
- Following ocular administration, bromfenac penetrates the cornea and achieves therapeutic concentrations in the anterior chamber of the eye.
- Systemic absorption of bromfenac after ocular administration is minimal.
- Bromfenac is extensively metabolized in the liver, and its metabolites are eliminated primarily in the urine.
Pharmacodynamics (PD):
- Bromfenac exerts its pharmacodynamic effects by inhibiting prostaglandin synthesis, thereby reducing inflammation and pain associated with ocular conditions such as cataract surgery.
Pathophysiology:
- Bromfenac is indicated for the treatment of postoperative inflammation and reduction of ocular pain following cataract surgery.
Indications:
- Ophthalmic bromfenac is indicated for the treatment of postoperative inflammation and reduction of ocular pain following cataract surgery.
- Systemic bromfenac tablets may be prescribed for the management of pain and inflammation associated with osteoarthritis or rheumatoid arthritis.
Contraindications:
- Contraindications to the use of bromfenac include hypersensitivity to the drug or its components, history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
Drug Interactions:
- Bromfenac may interact with other medications, including other NSAIDs, corticosteroids, anticoagulants, antiplatelet drugs, and selective serotonin reuptake inhibitors (SSRIs).
- Concomitant use of bromfenac with other NSAIDs or corticosteroids may increase the risk of gastrointestinal bleeding or ulceration.
Monitoring and Laboratory Tests:
- Patients receiving bromfenac therapy may require monitoring of intraocular pressure, especially in those with preexisting glaucoma or risk factors for ocular hypertension.
- Laboratory tests, including renal function tests and complete blood count (CBC), may be performed periodically to assess for potential adverse effects of NSAID therapy.
It’s essential to use bromfenac under the guidance and supervision of a qualified healthcare provider, who can determine the appropriate dosage, frequency, and duration of treatment based on individual patient factors and clinical considerations.
Why is this medication prescribed?
- Bromfenac is prescribed to reduce inflammation and pain in the eye following cataract surgery. It belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs) and helps prevent swelling and discomfort in the eye after the procedure.
How should this medicine be used?
- Bromfenac is typically administered as eye drops. Follow your doctor’s instructions carefully regarding the dosage and frequency of administration.
- Wash your hands before using the eye drops. Tilt your head back, pull down the lower eyelid, and instill the prescribed number of drops into the eye(s) as directed.
- Avoid touching the tip of the dropper to prevent contamination.
- If you wear contact lenses, remove them before applying the eye drops and wait at least 15 minutes before reinserting them.
Other uses for this medicine
- Bromfenac is primarily used for postoperative eye care following cataract surgery. It is not typically used for other conditions.
What special precautions should I follow?
- Inform your doctor if you have any allergies to NSAIDs, eye medications, or any other substances.
- Let your doctor know if you have a history of asthma, bleeding disorders, or other eye conditions.
- Avoid driving or operating machinery immediately after using bromfenac eye drops, as they may cause temporary blurred vision.
What special dietary instructions should I follow?
- There are no specific dietary restrictions associated with the use of bromfenac eye drops.
What should I do if I forget a dose?
- If you forget to use a dose of bromfenac eye drops, apply it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
What side effects can this medication cause?
- Common side effects of bromfenac eye drops may include temporary stinging or burning sensation in the eyes, blurred vision, eye irritation, or dryness.
- Less common but more severe side effects may include eye pain, swelling, redness, sensitivity to light, or changes in vision. If you experience any of these symptoms, contact your doctor immediately.
What should I know about storage and disposal of this medication?
- Store bromfenac eye drops at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
- Do not share your medication with others, and do not use it for any condition other than the one prescribed.
- Dispose of any unused or expired medication according to local regulations.
In case of emergency/overdose
- If you suspect an overdose or experience severe irritation or adverse effects after using bromfenac eye drops, seek medical attention or contact a poison control center immediately.