Table of Contents
Dosage and Frequency: #
- The usual adult dose for Griseofulvin is 500 to 1000 mg orally once daily or in divided doses.
- Pediatric dosing depends on the weight of the child, typically ranging from 10 to 20 mg/kg/day.
Route of Administration (ROA): #
- Griseofulvin is administered orally in the form of tablets or liquid suspension.
Mechanism of Action (MOA): #
- Griseofulvin works by binding to microtubules and interfering with the mitotic spindle function of fungal cells, inhibiting their replication and causing cell death.
Pharmacokinetics (PK): #
- Griseofulvin is absorbed better when taken with a fatty meal, as it is lipophilic.
- It undergoes hepatic metabolism via cytochrome P450 enzymes, primarily CYP3A4, and is excreted in the feces and urine.
Pathophysiology: #
- Griseofulvin disrupts fungal cell division by inhibiting microtubule formation, leading to the arrest of fungal growth.
Indications: #
- It is used in the treatment of dermatophyte infections, including tinea capitis, tinea corporis, tinea pedis, and tinea cruris.
Contraindications: #
- Contraindications include hypersensitivity to griseofulvin, porphyria, severe liver disease, and pregnancy.
Drug Interactions: #
- Griseofulvin may interact with drugs that induce or inhibit cytochrome P450 enzymes, such as rifampin, phenobarbital, and ketoconazole.
Precautions: #
- Caution is advised in patients with liver disease, as griseofulvin is metabolized by the liver and can exacerbate existing hepatic impairment.
Monitoring and Laboratory Tests: #
- Liver function tests should be monitored periodically, especially in patients with pre-existing liver disease or those on long-term therapy.
- Blood counts may be monitored due to the potential for hematologic adverse effects, such as leukopenia and thrombocytopenia.
Medication Information and Guidelines
| Purpose: Griseofulvin is used to treat fungal infections of the skin, hair, and nails, such as ringworm and athlete’s foot. It works by stopping the growth of fungi. Usage: Take this medication by mouth with food or milk as directed by your doctor. Dosage and duration of treatment depend on your medical condition and response to therapy. For best results, take it regularly as prescribed. Other Uses: Griseofulvin may be prescribed for conditions not listed here. It’s essential to follow your doctor’s instructions carefully. Precautions: Inform your doctor of any allergies or medical conditions you have, especially liver disease. Avoid exposure to sunlight or tanning beds, as griseofulvin may make your skin more sensitive to sunlight. Dietary Changes: There are no specific dietary restrictions while taking griseofulvin, but it’s essential to maintain a balanced diet to support overall health. Missed Dose: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. Side Effects: Common side effects include nausea, vomiting, diarrhea, headache, and dizziness. Notify your doctor promptly if you experience severe side effects such as persistent nausea, stomach/abdominal pain, dark urine, or yellowing eyes/skin. Storage: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Disposal: Dispose of unused medication properly, following local guidelines or by consulting with your pharmacist. Emergency: In case of overdose or emergency, contact your local poison control center or seek immediate medical attention. |
