| Drug | Medication Information and Guidelines |
|---|---|
| Recommended Dose and Dosage Regimen | The recommended dose of indapamide for hypertension is usually 1.25 mg to 2.5 mg orally once daily, preferably in the morning with breakfast. |
| Frequency of Administration | Indapamide is typically administered once daily. |
| Route of Administration | The drug is administered orally, usually with a glass of water. |
| Mechanism of Action (MOA) | Indapamide is a thiazide-like diuretic that works by inhibiting sodium reabsorption in the distal convoluted tubules of the kidneys. |
| Pharmacokinetics (PK) | After oral administration, indapamide is rapidly absorbed, reaching peak plasma concentrations within 2 to 5 hours. |
| Pharmacodynamics (PD) | Indapamide promotes diuresis by increasing urine volume and decreasing plasma volume and blood pressure. |
| Pathophysiology | Indapamide is primarily indicated for the treatment of hypertension, reducing blood pressure by promoting diuresis and vasodilation. |
| Primary Indications | The primary indication for prescribing indapamide is the management of hypertension (high blood pressure). |
| Contraindications | Contraindications include severe renal impairment, anuria, hepatic coma or precoma associated with hepatic cirrhosis, and hypersensitivity to the drug. |
| Purpose of Taking Medication | Indapamide is used to lower blood pressure and reduce the risk of complications associated with hypertension, such as stroke and heart attack. |
| How is one Supposed to Use this Medicine? | Take indapamide orally, usually once daily in the morning with breakfast, unless otherwise directed by a healthcare provider. |
| Other Reasons for Using this Medication | Indapamide may also be used in the treatment of edema associated with heart failure when other diuretics are ineffective. |
| Specific Precautions | Patients should be monitored for electrolyte imbalances, particularly potassium levels, during treatment with indapamide. |
| Dietary Considerations | Patients may be advised to consume a diet rich in potassium or to take potassium supplements to prevent hypokalemia. |
| What to Do if a Dose is Missed | If a dose is missed, it should be taken as soon as remembered unless it is almost time for the next scheduled dose. |
| Possible Side Effects | Common side effects include hypokalemia, hyponatremia, hypomagnesemia, dizziness, headache, and gastrointestinal disturbances. |
| Storage and Disposal | Store indapamide tablets at room temperature away from moisture and heat. Dispose of unused or expired medication properly. |
| Emergency Situations | In case of an overdose or emergency situation, seek medical assistance immediately. Symptoms may include severe electrolyte imbalances or dehydration. |
| Monitoring and Laboratory Tests | Regular monitoring of electrolytes (potassium, sodium, magnesium) and renal function (creatinine clearance) may be required during treatment. |
This table provides comprehensive information and guidelines for the use of indapamide as a medication for hypertension. Always consult a healthcare professional for personalized advice and recommendations.