Ceftriaxone/sulbactam – Dose, ROA, MOA, PK, PD, Indications & More

Dose and Dosage:

  • The dosage of ceftriaxone/sulbactam depends on various factors such as the severity of the infection, patient’s age, weight, and renal function.
  • It is typically administered intravenously (IV).

Frequency:

  • The frequency of administration varies depending on the condition being treated, but it is usually given once or twice a day.

Route of Administration (ROA):

  • Ceftriaxone/sulbactam is administered intravenously (IV) by a healthcare professional.

Mechanism of Action (MOA):

  • Ceftriaxone is a third-generation cephalosporin antibiotic that works by inhibiting bacterial cell wall synthesis.
  • Sulbactam is a beta-lactamase inhibitor that helps extend the antibacterial activity of ceftriaxone by inhibiting the enzymes that can deactivate it.

Pharmacokinetics (PK):

  • Ceftriaxone has a long half-life, allowing for once-daily dosing.
  • Sulbactam is rapidly absorbed after IV administration and has a short elimination half-life.

Pharmacodynamics (PD):

  • Ceftriaxone/sulbactam exhibits time-dependent bactericidal activity.

Pathophysiology:

  • Ceftriaxone/sulbactam is used to treat bacterial infections caused by susceptible organisms.

Indications:

  • It is indicated for the treatment of various infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, intra-abdominal infections, and septicemia caused by susceptible bacteria.

Contraindications:

  • Hypersensitivity to cephalosporins or beta-lactamase inhibitors.
  • Previous severe hypersensitivity reactions to penicillins, cephalosporins, or other beta-lactams.

Drug Interactions:

  • Ceftriaxone/sulbactam may interact with other medications, including anticoagulants, probenecid, and certain nephrotoxic drugs.

Monitoring and Laboratory Tests:

  • Monitoring of renal function and liver function tests may be necessary during treatment.
  • Culture and sensitivity testing should be performed to guide antibiotic therapy.

Please note that the specific dosing and usage instructions should be determined by a healthcare professional based on individual patient factors and the specific infection being treated.


Why is this medication prescribed?

  • Ceftriaxone/sulbactam is prescribed to treat various bacterial infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, intra-abdominal infections, and septicemia caused by susceptible organisms.

How should this medicine be used?

  • It is typically administered intravenously (IV) by a healthcare professional.
  • The dosage and frequency of administration will depend on factors such as the severity of the infection, patient’s age, weight, and renal function.
  • It is important to follow the instructions provided by your healthcare provider.

Other uses for this medicine

  • Ceftriaxone/sulbactam is primarily used for bacterial infections and is not typically used for other purposes.

What special precautions should I follow?

  • Inform your healthcare provider about any allergies or previous reactions to cephalosporins, penicillins, or other beta-lactam antibiotics.
  • Be sure to inform your doctor about any other medications you are taking, including over-the-counter drugs and supplements.

What special dietary instructions should I follow?

  • There are typically no specific dietary restrictions associated with ceftriaxone/sulbactam use. However, it’s essential to follow a balanced diet and stay hydrated while undergoing treatment for an infection.

What should I do if I forget a dose?

  • If you miss a dose, contact your healthcare provider for advice on when to take the next dose. Do not double up on doses to make up for a missed one.

What side effects can this medication cause?

  • Common side effects may include diarrhea, nausea, vomiting, headache, and injection site reactions.
  • Serious side effects are rare but may include allergic reactions, severe skin reactions, or intestinal inflammation.

What should I know about storage and disposal of this medication?

  • Ceftriaxone/sulbactam should be stored at room temperature away from light and moisture.
  • It is typically supplied as a powder for injection, which should be reconstituted with a suitable diluent as directed by your healthcare provider.

In case of emergency/overdose

  • If you suspect an overdose or experience severe side effects, seek medical attention immediately or contact a poison control center.
  • Be sure to inform healthcare providers of all medications you have taken and any symptoms you are experiencing.